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事件日期	中文股东名称	持股人名字	涉及股份(股)	先前结余(股)	先前结余率(%)	先前类别	目前结余(股)	目前结余率(%)	目前类别	股份类别
2024-12-09	JPMorgan Chase & Co.	JPMorgan Chase & Co.	12901557	126171100	0.0992	L	139072657	0.1094	L	普通股
2024-12-03	HHLR Fund, L.P.	HHLR Fund, L.P.	17842500	129439923	0.0934	L	111597423	0.0805	L	普通股
2024-12-03	HHLR Advisors, Ltd.	HHLR Advisors, Ltd.	17842500	129439923	0.0934	L	111597423	0.0805	L	普通股
2024-09-24	JPMorgan Chase & Co.	JPMorgan Chase & Co.	15073484	126773864	0.1003	L	111700380	0.0883	L	普通股
2023-11-14	JPMorgan Chase & Co.	JPMorgan Chase & Co.	14466486	89513178	0.0722	L	103979664	0.0839	L	普通股
2023-11-14	Baker Julian Charles	Baker Julian Charles	14300000	153057831	0.1126	L	138757831	0.1021	L	普通股
2023-11-14	Baker Felix James	Baker Felix James	14300000	153057831	0.1126	L	138757831	0.1021	L	普通股
2023-11-14	Baker Bros. Advisors (GP) LLC	Baker Bros. Advisors (GP) LLC	14300000	152602171	0.1122	L	138302171	0.1017	L	普通股
2023-11-08	JPMorgan Chase & Co.	JPMorgan Chase & Co.	13599866	103921344	0.0839	L	90321478	0.0729	L	普通股
2022-12-15	JPMorgan Chase & Co.	JPMorgan Chase & Co.	77271771	24227395	0.0179	L	101499166	0.0751	L	普通股
2022-03-10	JPMorgan Chase & Co.	JPMorgan Chase & Co.	78035946	104024002	0.0780	L	25988056	0.0194	L	普通股
2021-10-15	JPMorgan Chase & Co.	JPMorgan Chase & Co.	12583530	92113680	0.0759	L	104697210	0.0862	L	普通股
2020-12-02	Baker Bros. Advisors (GP) LLC	Baker Bros. Advisors (GP) LLC	19650098	173594207	0.1469	L	153944109	0.1302	L	普通股
2020-12-02	Baker Felix James	Baker Felix James	19650098	174056354	0.1472	L	154406256	0.1306	L	普通股
2020-12-02	Baker Julian Charles	Baker Julian Charles	19650098	174056354	0.1472	L	154406256	0.1306	L	普通股
2020-12-02	Baker Brothers Life Sciences Capital, L.P.	Baker Brothers Life Sciences Capital, L.P.	18018429	159235478	0.1347	L	141217049	0.1195	L	普通股
2020-07-13	Amgen Inc.	Amgen Inc.	29614832	206635013	0.2031	L	236249845	0.2322	L	普通股
2020-07-12	Hillhouse Capital Advisors, Ltd.	Hillhouse Capital Advisors, Ltd.	70270109	63317546	0.0622	L	133587655	0.1313	L	普通股
2020-07-12	Gaoling Fund, L.P.	Gaoling Fund, L.P.	70270109	59162950	0.0581	L	129433059	0.1272	L	普通股
2020-07-12	Hillhouse Capital Advisors, Ltd.	Hillhouse Capital Advisors, Ltd.	70270109	63317546	0.0622	L	133587655	0.1313	L	普通股
2020-07-12	Baker Brothers Life Sciences Capital, L.P.	Baker Brothers Life Sciences Capital, L.P.	13589904	145645574	0.1431	L	159235478	0.1565	L	普通股
2020-07-12	Baker Bros. Advisors (GP) LLC	Baker Bros. Advisors (GP) LLC	14584180	159010027	0.1563	L	173594207	0.1706	L	普通股
2020-07-12	BakerJulian Charles	BakerJulian Charles	14584180	159472174	0.1567	L	174056354	0.1710	L	普通股
2020-07-12	BakerFelix James	BakerFelix James	14584180	159472174	0.1567	L	174056354	0.1710	L	普通股
2020-06-15	JPMorgan Chase & Co.	JPMorgan Chase & Co.	38447970	38837174	0.0384	L	77285144	0.0764	L	普通股
2020-04-17	JPMorgan Chase & Co.	JPMorgan Chase & Co.	48988059	87476156	0.0870	L	38488097	0.0382	L	普通股
2020-04-09	JPMorgan Chase & Co.	JPMorgan Chase & Co.	20018962	106682983	0.1061	L	86664021	0.0861	L	普通股
2020-04-08	JPMorgan Chase & Co.	JPMorgan Chase & Co.	0	85414437	0.0849	L	106682983	0.1061	L	普通股
2020-03-12	JPMorgan Chase & Co.	JPMorgan Chase & Co.	39652854	49232570	0.0490	L	88885424	0.0885	L	普通股
2019-10-31	Amgen Inc.	Amgen Inc.	0	0	0.0000	L	203282820	0.2050	L	普通股
2019-01-01	Hillhouse Capital Management, Ltd.	Hillhouse Capital Management, Ltd.	63117389	76563367	0.0989	L	13445978	0.0174	L	普通股
2019-01-01	Hillhouse Capital Advisors, Ltd.	Hillhouse Capital Advisors, Ltd.	63117389	0	0.0000	L	63117389	0.0816	L	普通股
2018-12-26		Wellington Management Group LLP	377221	38474839	5.0300	L	38097618	4.9800	L	H Shares
2018-12-26		Wellington Management Group LLP		38675	0.0100	S	38675	0.0100	S	H Shares
2018-12-06		FMR LLC	1677000	78936136	10.2000	L	78936136	10.2000	L	Ordinary Shares
2018-12-04		FMR LLC	1677000	78928141	10.2000	L	78928141	10.2000	L	Ordinary Shares
2018-11-19		Wellington Management Group LLP	386399	37971973	4.9700	L	38358372	5.0200	L	H Shares
2018-11-05		Wellington Management Group LLP	946946	38842310	5.0800	L	37895364	4.9600	L	H Shares
2018-10-24		Wellington Management Group LLP	957567	45339286	5.8800	L	46296853	6.0000	L	H Shares
2018-10-11		Wellington Management Group LLP	560391	37694865	4.9300	L	38255256	5.0000	L	H Shares
2018-09-11		Wellington Management Group LLP	83642	38453845	5.0000	L	38537487	5.0100	L	H Shares
2018-08-22		FIDELITY MT.VERNON STREET TRUST	46605	38346489	4.9900	L	38393094	5.0000	L	Ordinary Shares
2018-08-08	欧雷强	欧雷强	83059369	0	0.0000	L	83059369	0.1083	L	普通股
2018-08-08	Gaoling Fund, L.P.	Gaoling Fund, L.P.	0	0	0.0000	L	58995800	0.0769	L	普通股
2018-08-08	Hillhouse Capital Management, Ltd.	Hillhouse Capital Management, Ltd.	0	0	0.0000	L	76563367	0.0998	L	普通股
2018-08-08	FMR Co., Inc.	FMR Co., Inc.	0	0	0.0000	L	71180714	0.0928	L	普通股
2018-08-08	Fidelity Management & Research Company	Fidelity Management & Research Company	0	0	0.0000	L	76202408	0.0993	L	普通股
2018-08-08	FMR LLC	FMR LLC	0	0	0.0000	L	77169208	0.1006	L	普通股
2018-08-08	王晓东	王晓东	21483959	0	0.0000	L	21483959	0.0280	L	普通股
2018-08-08	高瓴资本管理有限公司	Hillhouse Capital Management,Ltd.					76563367	9.9800	L	Ordinary Shares
2018-08-08		Gaoling Fund, L.P.					58995800	7.6900	L	Ordinary Shares
2018-08-08		FMR LLC					77169208	10.0600	L	Ordinary Shares
2018-08-08		FMR Co., Inc					71180714	9.2800	L	Ordinary Shares
2018-08-08		Fidelity Management & Research Company					76202408	9.9300	L	Ordinary Shares
2018-08-08		Baker Brothers Life Sciences Capital, L.P.	5231900	140193722	18.2700	L	145425622	18.9600	L	Ordinary Shares
2018-08-08		Baker Felix James	5814100	156066577	20.3400	L	161880677	21.1000	L	Ordinary Shares
2018-08-08		Baker Julian Charles	5814100	156066577	20.3400	L	161880677	21.1000	L	Ordinary Shares
2018-08-08		Baker Bros. Advisors (GP) LLC	5814100	155931182	20.3300	L	161745282	21.0800	L	Ordinary Shares