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事件日期	中文股东名称	持股人名字	涉及股份(股)	先前结余(股)	先前结余率(%)	先前类别	目前结余(股)	目前结余率(%)	目前类别	股份类别
2025-11-27	JPMorgan Chase & Co.	JPMorgan Chase & Co.	90694840	277666309	0.1451	L	186971469	0.0977	L	普通股
2025-11-24	JPMorgan Chase & Co.	JPMorgan Chase & Co.	89060433	187317117	0.0979	L	276377550	0.1444	L	普通股
2025-11-13	Maxwell Maxcare Science Foundation Limited	Maxwell Maxcare Science Foundation Limited	20987935	480827182	0.2514	L	501815117	0.2623	L	普通股
2025-11-13	We'Tron Capital Limited	We'Tron Capital Limited	20987935	477543948	0.2496	L	498531883	0.2606	L	普通股
2025-08-04	上海市浦东新区国有资产监督管理委员会	上海市浦东新区国有资产监督管理委员会	135335204	0	0.0000	L	135335204	0.0731	L	普通股
2025-07-25	We'Tron Capital Limited	We'Tron Capital Limited	135335204	342208744	0.1850	L	477543948	0.2581	L	普通股
2025-07-25	Otsuka Medical Devices Co., Ltd.	Otsuka Medical Devices Co., Ltd.	290670408	382994120	0.2013	L	92323712	0.0485	L	普通股
2025-07-25	Otsuka Holdings Co., Ltd.	Otsuka Holdings Co., Ltd.	290670408	382994120	0.2013	L	92323712	0.0485	L	普通股
2025-07-25	Otsuka Holdings Co., Ltd.	Otsuka Holdings Co., Ltd.	290670408	382994120	0.2013	L	92323712	0.0485	L	普通股
2025-07-25	Otsuka Medical Devices Co., Ltd.	Otsuka Medical Devices Co., Ltd.	290670408	382994120	0.2013	L	92323712	0.0485	L	普通股
2025-07-25	Otsuka Medical Devices Co., Ltd.	Otsuka Medical Devices Co., Ltd.	290670408	382994120	0.2060	L	92323712	0.0497	L	普通股
2025-07-25	Otsuka Medical Devices Co., Ltd.	Otsuka Medical Devices Co., Ltd.	290670408	382994120	0.2060	L	92323712	0.0497	L	普通股
2025-07-25	Otsuka Holdings Co., Ltd.	Otsuka Holdings Co., Ltd.	290670408	382994120	0.2060	L	92323712	0.0497	L	普通股
2025-07-25	Otsuka Holdings Co., Ltd.	Otsuka Holdings Co., Ltd.	290670408	382994120	0.2060	L	92323712	0.0497	L	普通股
2025-07-25	Otsuka Holdings Co., Ltd.	Otsuka Holdings Co., Ltd.	290670408	382994120	0.2070	L	92323712	0.0499	L	普通股
2025-07-25	Otsuka Medical Devices Co., Ltd.	Otsuka Medical Devices Co., Ltd.	290670408	382994120	0.2070	L	92323712	0.0499	L	普通股
2025-07-25	上海市财政局	上海市财政局	135335204	0	0.0000	L	135335204	0.0731	L	普通股
2025-07-25	上海生物医药并购私募基金合伙企业（有限合伙）	上海生物医药并购私募基金合伙企业（有限合伙）	135335204	0	0.0000	L	135335204	0.0731	L	普通股
2025-07-25	上海上实生物医药管理咨询有限公司	上海上实生物医药管理咨询有限公司	135335204	0	0.0000	L	135335204	0.0731	L	普通股
2025-07-25	上海迈泰克医疗器械合伙企业（有限合伙）	上海迈泰克医疗器械合伙企业（有限合伙）	135335204	0	0.0000	L	135335204	0.0731	L	普通股
2025-07-25	上海鹭布卡企业管理咨询合伙企业（有限合伙）	上海鹭布卡企业管理咨询合伙企业（有限合伙）	135335204	0	0.0000	L	135335204	0.0731	L	普通股
2025-07-25	上海市国有资产监督管理委员会	上海市国有资产监督管理委员会	135335204	0	0.0000	L	135335204	0.0731	L	普通股
2025-07-25	上海国投先导生物医药私募投资基金合伙企业（有限合伙）	上海国投先导生物医药私募投资基金合伙企业（有限合伙）	135335204	0	0.0000	L	135335204	0.0731	L	普通股
2025-07-25	刘大伟	刘大伟	135335204	0	0.0000	L	135335204	0.0731	L	普通股
2025-07-25	蒋骏航	蒋骏航	135335204	0	0.0000	L	135335204	0.0731	L	普通股
2025-07-25	Maxwell Maxcare Science Foundation Limited	Maxwell Maxcare Science Foundation Limited	135335204	345491978	0.1867	L	480827182	0.2599	L	普通股
2025-07-25	Otsuka Medical Devices Co., Ltd.	Otsuka Medical Devices Co., Ltd.	290670408	382994120	0.2070	L	92323712	0.0499	L	普通股
2025-07-25	Otsuka Holdings Co., Ltd.	Otsuka Holdings Co., Ltd.	290670408	382994120	0.2070	L	92323712	0.0499	L	普通股
2025-07-24	上海张江(集团)有限公司	上海张江(集团)有限公司	37000000	151748050	0.0820	L	114748050	0.0620	L	普通股
2024-12-11	Shaw David Elliot	Shaw David Elliot	26234919	82169844	0.0445	L	108404763	0.0587	L	普通股
2024-12-11	D. E. Shaw Valence Portfolios, L.L.C.	D. E. Shaw Valence Portfolios, L.L.C.	26234919	82169844	0.0445	L	108404763	0.0587	L	普通股
2024-12-11	D. E. Shaw & Co., Inc.	D. E. Shaw & Co., Inc.	26234919	82169844	0.0445	L	108404763	0.0587	L	普通股
2024-12-11	D. E. Shaw & Co. II, Inc.	D. E. Shaw & Co. II, Inc.	26234919	82169844	0.0445	L	108404763	0.0587	L	普通股
2024-12-11	D. E. Shaw & Co., L.L.C.	D. E. Shaw & Co., L.L.C.	26234919	82169844	0.0445	L	108404763	0.0587	L	普通股
2024-12-11	D. E. Shaw & Co., L.P.	D. E. Shaw & Co., L.P.	26234919	82169844	0.0445	L	108404763	0.0587	L	普通股
2024-09-23	HHLR Advisors, Ltd.	HHLR Advisors, Ltd.	55000000	145774600	0.0794	L	90774600	0.0495	L	普通股
2024-09-23	HHLR Fund, L.P.	HHLR Fund, L.P.	55000000	145774600	0.0794	L	90774600	0.0495	L	普通股
2024-09-20	JPMorgan Chase & Co.	JPMorgan Chase & Co.	42705329	215791391	0.1176	L	173086062	0.0943	L	普通股
2024-08-28	JPMorgan Chase & Co.	JPMorgan Chase & Co.	49361369	165927226	0.0904	L	215288595	0.1173	L	普通股
2024-08-27	JPMorgan Chase & Co.	JPMorgan Chase & Co.	24815512	190742738	0.1039	L	165927226	0.0904	L	普通股
2024-07-23	JPMorgan Chase & Co.	JPMorgan Chase & Co.	26387383	210515766	0.1147	L	184128383	0.1003	L	普通股
2024-07-05	JPMorgan Chase & Co.	JPMorgan Chase & Co.	19184443	222329074	0.1211	L	203144631	0.1107	L	普通股
2024-06-27	Fischer Seth Hillel	Fischer Seth Hillel	20987935	72961239	0.0398	L	93949174	0.0512	L	普通股
2024-06-27	Oasis Management Company Ltd.	Oasis Management Company Ltd.	20987935	72961239	0.0398	L	93949174	0.0512	L	普通股
2024-06-27	Oasis Investments II Master Fund Ltd.	Oasis Investments II Master Fund Ltd.	20987935	72961239	0.0398	L	93949174	0.0512	L	普通股
2024-06-27	Oasis Investments II Offshore Feeder Ltd.	Oasis Investments II Offshore Feeder Ltd.	20987935	72961239	0.0398	L	93949174	0.0512	L	普通股
2024-05-29	Hillhouse Investment Management, Ltd.	Hillhouse Investment Management, Ltd.	131174597	157409516	0.0858	L	26234919	0.0143	L	普通股
2024-05-26	Hillhouse Investment Management, Ltd.	Hillhouse Investment Management, Ltd.	20987935	136421581	0.0744	L	157409516	0.0858	L	普通股
2024-05-24	JPMorgan Chase & Co.	JPMorgan Chase & Co.	36562946	200328551	0.1091	L	236891497	0.1291	L	普通股
2024-05-20	上海张江(集团)有限公司	上海张江(集团)有限公司	20000000	171748050	0.0936	L	151748050	0.0827	L	普通股
2024-04-25	JPMorgan Chase & Co.	JPMorgan Chase & Co.	21061764	242750615	0.1323	L	221688851	0.1208	L	普通股
2024-04-05	Hillhouse Investment Management, Ltd.	Hillhouse Investment Management, Ltd.	136421581	0	0.0000	L	136421581	0.0744	L	普通股
2024-04-05	HFTY I Holdings Pte. Ltd.	HFTY I Holdings Pte. Ltd.	52469839	0	0.0000	L	52469839	0.0286	L	普通股
2024-04-05	Hillhouse Investment Management, Ltd.	Hillhouse Investment Management, Ltd.	188891653	0	0.0000	L	188891653	0.1030	L	普通股
2024-04-05	HFTY I Holdings Pte. Ltd.	HFTY I Holdings Pte. Ltd.	104939807	0	0.0000	L	104939807	0.0572	L	普通股
2023-12-19	JPMorgan Chase & Co.	JPMorgan Chase & Co.	29104320	289243781	0.1576	L	260139461	0.1418	L	普通股
2023-12-12	JPMorgan Chase & Co.	JPMorgan Chase & Co.	20024225	284082125	0.1548	L	304106350	0.1657	L	普通股
2023-12-07	JPMorgan Chase & Co.	JPMorgan Chase & Co.	30834039	270952370	0.1477	L	301786409	0.1645	L	普通股
2023-12-06	JPMorgan Chase & Co.	JPMorgan Chase & Co.	185848444	85103926	0.0463	L	270952370	0.1477	L	普通股
2023-01-20	We'Tron Capital Limited	We'Tron Capital Limited	78732871	264291373	0.1446	L	343024244	0.1877	L	普通股
2023-01-04	上海张江(集团)有限公司	上海张江(集团)有限公司	22670000	194418050	0.1064	L	171748050	0.0940	L	普通股
2021-09-30	常兆华	常兆华	0	92978280	0.0511	L	29928417	0.0164	L	普通股
2021-09-30	Maxwell Maxcare Science Foundation Limited	Maxwell Maxcare Science Foundation Limited	63049863	265313492	0.1458	L	328363355	0.1804	L	普通股
2020-12-18	Maxwell Maxcare Science Foundation Limited	Maxwell Maxcare Science Foundation Limited	26158884	238948304	0.1321	L	265107188	0.1465	L	普通股
2020-12-18	We'Tron Capital Limited	We'Tron Capital Limited	26158884	237926980	0.1315	L	264085864	0.1460	L	普通股
2020-12-18	Shanghai We'Tron Capital Corp.	Shanghai We'Tron Capital Corp.	26158884	237926980	0.1315	L	264085864	0.1460	L	普通股
2020-06-23	Hillhouse Capital Advisors, Ltd.	Hillhouse Capital Advisors, Ltd.	33000000	120694000	0.0695	L	153694000	0.0885	L	普通股
2020-06-23	Gaoling Fund, L.P.	Gaoling Fund, L.P.	32946000	114063000	0.0657	L	147009000	0.0847	L	普通股
2020-03-23	JPMorgan Chase & Co.	JPMorgan Chase & Co.	43293030	88445660	0.0512	L	45152630	0.0261	L	普通股
2020-03-10	Carlyle Asia Partners, IV L.P.	Carlyle Asia Partners, IV L.P.	71590811	108859919	0.0631	L	37269108	0.0216	L	普通股
2020-03-10	JPMorgan Chase & Co.	JPMorgan Chase & Co.	56948000	54143230	0.0313	L	111091230	0.0643	L	普通股
2020-03-10	CAP IV General Partner, L.P.	CAP IV General Partner, L.P.	71590811	108859919	0.0631	L	37269108	0.0216	L	普通股
2020-03-10	CAP IV General Partner, L.P.	CAP IV General Partner, L.P.	71590811	108859919	0.0631	L	37269108	0.0216	L	普通股
2020-03-10	Erudite Holdings Limited	Erudite Holdings Limited	71590811	108859919	0.0631	L	37269108	0.0216	L	普通股
2020-03-10	CAP IV, L.L.C.	CAP IV, L.L.C.	71590811	108859919	0.0631	L	37269108	0.0216	L	普通股
2020-03-06	Gaoling Fund, L.P.	Gaoling Fund, L.P.	47734000	66329000	0.0384	L	114063000	0.0661	L	H股
2020-03-06	Hillhouse Capital Advisors, Ltd.	Hillhouse Capital Advisors, Ltd.	49986000	70708000	0.0410	L	120694000	0.0699	L	H股
2018-11-20	CAP IV, L.L.C.	CAP IV, L.L.C.	50000000	158238011	0.0988	L	108238011	0.0676	L	普通股
2018-11-20	Erudite Holdings Limited	Erudite Holdings Limited	50000000	158238011	0.0988	L	108238011	0.0676	L	普通股
2018-11-20	CAP IV General Partner, L.P.	CAP IV General Partner, L.P.	50000000	158238011	0.0988	L	108238011	0.0676	L	普通股
2018-11-20	Carlyle Asia Partners, IV L.P.	Carlyle Asia Partners, IV L.P.	50000000	158238011	0.0988	L	108238011	0.0676	L	普通股
2018-11-20		CAP IV General Partner, L.P.	50000000	158238011	9.8800	L	108238011	6.7600	L	Ordinary Shares
2018-11-20		CAP IV, L.L.C.	50000000	158238011	9.8800	L	108238011	6.7600	L	Ordinary Shares
2018-11-20		Carlyle Asia Partners IV, L.P.	50000000	158238011	9.8800	L	108238011	6.7600	L	Ordinary Shares
2018-11-20		Erudite Holdings Limited	50000000	158238011	9.8800	L	108238011	6.7600	L	Ordinary Shares
2018-11-20		Erudite Holdings Limited		37056193	2.3100	S	37056193	2.3100	S	Ordinary Shares
2018-11-20		Carlyle Asia Partners IV, L.P.		37056193	2.3100	S	37056193	2.3100	S	Ordinary Shares
2018-11-20		CAP IV, L.L.C.		37056193	2.3100	S	37056193	2.3100	S	Ordinary Shares
2018-11-20		CAP IV General Partner, L.P.		37056193	2.3100	S	37056193	2.3100	S	Ordinary Shares
2018-11-14		We'Tron Capital Limited	16037104	234384296	14.6300	L	234384296	14.6300	L	Ordinary Shares
2018-11-14		Shanghai We'Tron Capital Corp.	16037104	234384296	14.6300	L	234384296	14.6300	L	Ordinary Shares
2018-11-14	尽善尽美科学基金会有限公司	Maxwell Maxcare Science Foundation Limited	16037104	234384296	14.6300	L	234384296	14.6300	L	Ordinary Shares
2018-11-13	Grand Eternity Limited	Grand Eternity Limited	16037104	113669590	0.0717	L	97632486	0.0615	L	普通股
2018-11-13	East Mega Limited	East Mega Limited	16037104	113669590	0.0717	L	97632486	0.0615	L	普通股
2018-11-13	Helix Capital Partners	Helix Capital Partners	16037104	113669590	0.0717	L	97632486	0.0615	L	普通股
2018-11-13	East Image Limited	East Image Limited	16037104	113669590	0.0717	L	97632486	0.0615	L	普通股
2018-11-13	Starwick Investments Limited	Starwick Investments Limited	16037104	113669590	0.0717	L	97632486	0.0615	L	普通股
2018-11-13	We'Tron Capital Limited	We'Tron Capital Limited	16037104	218347192	0.1376	L	234384296	0.1478	L	普通股
2018-11-13	Shanghai We'Tron Capital Corp.	Shanghai We'Tron Capital Corp.	16037064	218347192	0.1376	L	234384296	0.1478	L	普通股
2018-11-13	Maxwell Maxcare Science Foundation Limited	Maxwell Maxcare Science Foundation Limited	16037104	218347192	0.1376	L	234384296	0.1478	L	普通股
2018-11-13		Starwick Investments Limited	16037104	113669590	7.1700	L	97632486	6.1500	L	Ordinary Shares
2018-11-13		Helix Capital Partners	16037104	113669590	7.1700	L	97632486	6.1500	L	Ordinary Shares
2018-11-13		Grand Eternity Limited	16037104	113669590	7.1700	L	97632486	6.1500	L	Ordinary Shares
2018-11-13		East Mega Limited	16037104	113669590	7.1700	L	97632486	6.1500	L	Ordinary Shares
2018-11-13		East Image Limited	16037104	113669590	7.1700	L	97632486	6.1500	L	Ordinary Shares
2018-11-13		Shanghai We'Tron Capital Corp.	16037064	218347192	13.7600	L	234384296	14.7800	L	Ordinary Shares
2018-11-13		We'Tron Capital Limited	16037104	218347192	13.7600	L	234384296	14.7800	L	Ordinary Shares
2018-11-13	尽善尽美科学基金会有限公司	Maxwell Maxcare Science Foundation Limited	16037104	218347192	13.7600	L	234384296	14.7800	L	Ordinary Shares
2018-11-12		CAP IV General Partner, L.P.		37056193	2.5300	S	37056193	2.3400	S	Ordinary Shares
2018-11-12		CAP IV, L.L.C.		37056193	2.5300	S	37056193	2.3400	S	Ordinary Shares
2018-11-12		Erudite Holdings Limited		37056193	2.5300	S	37056193	2.3400	S	Ordinary Shares
2018-11-12		Carlyle Asia Partners IV, L.P.		37056193	2.5300	S	37056193	2.3400	S	Ordinary Shares
2018-11-12		Carlyle Asia Partners IV, L.P.	121181818	158238011	10.8000	L	158238011	9.9800	L	Ordinary Shares
2018-11-12		Erudite Holdings Limited	121181818	158238011	10.8000	L	158238011	9.9800	L	Ordinary Shares
2018-11-12		CAP IV, L.L.C.	121181818	158238011	10.8000	L	158238011	9.9800	L	Ordinary Shares
2018-11-12		CAP IV General Partner, L.P.	121181818	158238011	10.8000	L	158238011	9.9800	L	Ordinary Shares
2018-08-16	尽善尽美科学基金会有限公司	Maxwell Maxcare Science Foundation Limited	544831	217802361	14.9000	L	218347192	14.9300	L	Ordinary Shares
2018-08-16		Shanghai We'Tron Capital Corp.	544831	217802361	14.9000	L	218347192	14.9300	L	Ordinary Shares
2018-08-16		We'Tron Capital Limited	544831	217802361	14.9000	L	218347192	14.9300	L	Ordinary Shares
2018-07-30	GIC Private Limited	GIC Private Limited	97528508	123331927	0.0844	L	25803418	0.0176	L	普通股
2018-07-30	GIC Special Investments Private Limited	GIC Special Investments Private Limited	97528508	123331927	0.0844	L	25803418	0.0176	L	普通股
2018-07-30	GIC (Ventures) Pte. Ltd.	GIC (Ventures) Pte. Ltd.	97528508	123331927	0.0844	L	25803418	0.0176	L	普通股
2018-07-30	Owap Investment Pte Ltd	Owap Investment Pte Ltd	97528508	123331927	0.0844	L	25803418	0.0176	L	普通股
2018-07-30		Owap Investment Pte Ltd.	97528508	123331927	8.4400	L	25803418	1.7600	L	Ordinary Shares
2018-07-30		GIC Special Investments Private Limited	97528508	123331927	8.4400	L	25803418	1.7600	L	Ordinary Shares
2018-07-30	新加坡政府投资公司	GIC Private Limited	97528508	123331927	8.4400	L	25803418	1.7600	L	Ordinary Shares
2018-07-30		GIC (Ventures) Pte. Ltd.	97528508	123331927	8.4400	L	25803418	1.7600	L	Ordinary Shares
2018-07-26	Grand Eternity Limited	Grand Eternity Limited	113669590	0	0.0000	L	113669590	0.0777	L	普通股
2018-07-26	East Mega Limited	East Mega Limited	113669590	0	0.0000	L	113669590	0.0777	L	普通股
2018-07-26	Helix Capital Partners	Helix Capital Partners	113669590	0	0.0000	L	113669590	0.0777	L	普通股
2018-07-26	East Image Limited	East Image Limited	113669590	0	0.0000	L	113669590	0.0777	L	普通股
2018-07-26	Starwick Investments Limited	Starwick Investments Limited	113669590	0	0.0000	L	113669590	0.0777	L	普通股
2018-07-26		GIC (Ventures) Pte. Ltd.		123331927	8.4400	L	123331927	8.4400	L	Ordinary Shares
2018-07-26	新加坡政府投资公司	GIC Private Limited		123331927	8.4400	L	123331927	8.4400	L	Ordinary Shares
2018-07-26		GIC Special Investments Private Limited		123331927	8.4400	L	123331927	8.4400	L	Ordinary Shares
2018-07-26		Owap Investment Pte Ltd.		123331927	8.4400	L	123331927	8.4400	L	Ordinary Shares
2018-07-26		East Image Limited	113669590	0	0.0000	L	113669590	7.7700	L	Ordinary Shares
2018-07-26		East Mega Limited	113669590	0	0.0000	L	113669590	7.7700	L	Ordinary Shares
2018-07-26		Grand Eternity Limited	113669590	0	0.0000	L	113669590	7.7700	L	Ordinary Shares
2018-07-26		Starwick Investments Limited	113669590	0	0.0000	L	113669590	7.7700	L	Ordinary Shares
2018-07-26		Helix Capital Partners	113669590	0	0.0000	L	113669590	7.7700	L	Ordinary Shares
2018-06-28		Mondrian Investment Partners Limited	336000	73820000	5.0500	L	72716000	4.9700	L	Ordinary Shares
2018-04-09		Erudite Holdings Limited	2006378	161456071	11.0800	L	159449693	10.9100	L	Ordinary Shares
2018-04-09		CAP IV General Partner, L.P.	2006378	161456071	11.0800	L	159449693	10.9100	L	Ordinary Shares
2018-04-09		CAP IV, L.L.C.	2006378	161456071	11.0800	L	159449693	10.9100	L	Ordinary Shares
2018-04-09		CAP IV General Partner, L.P.	2006378	40274253	2.7600	S	38267875	2.6200	S	Ordinary Shares
2018-04-09		Carlyle Asia Partners IV, L.P.	2006378	161456071	11.0800	L	159449693	10.9100	L	Ordinary Shares
2018-04-09		CAP IV, L.L.C.	2006378	40274253	2.7600	S	38267875	2.6200	S	Ordinary Shares
2018-04-09		Erudite Holdings Limited	2006378	40274253	2.7600	S	38267875	2.6200	S	Ordinary Shares
2018-04-09		Carlyle Asia Partners IV, L.P.	2006378	40274253	2.7600	S	38267875	2.6200	S	Ordinary Shares
2018-01-23	CAP IV, L.L.C.	CAP IV, L.L.C.	46000000	207456071	0.1424	L	161456071	0.1108	L	普通股
2018-01-23	Erudite Holdings Limited	Erudite Holdings Limited	46000000	207456071	0.1424	L	161456071	0.1108	L	普通股
2018-01-23	Carlyle Asia Partners, IV L.P.	Carlyle Asia Partners, IV L.P.	46000000	207456071	0.1424	L	161456071	0.1108	L	普通股
2018-01-23	CAP IV General Partner, L.P.	CAP IV General Partner, L.P.	46000000	207456071	0.1424	L	161456071	0.1108	L	普通股
2018-01-23		Carlyle Asia Partners IV, L.P.	46000000	207456071	14.2400	L	161456071	11.0800	L	Ordinary Shares
2018-01-23		Carlyle Asia Partners IV, L.P.	2000131	42274384	2.9000	S	40274253	2.7600	S	Ordinary Shares
2018-01-23		CAP IV General Partner, L.P.	46000000	207456071	14.2400	L	161456071	11.0800	L	Ordinary Shares
2018-01-23		CAP IV, L.L.C.	46000000	207456071	14.2400	L	161456071	11.0800	L	Ordinary Shares
2018-01-23		Erudite Holdings Limited	46000000	207456071	14.2400	L	161456071	11.0800	L	Ordinary Shares
2018-01-23		Erudite Holdings Limited	2000131	42274384	2.9000	S	40274253	2.7600	S	Ordinary Shares
2018-01-23		CAP IV, L.L.C.	2000131	42274384	2.9000	S	40274253	2.7600	S	Ordinary Shares
2018-01-23		CAP IV General Partner, L.P.	2000131	42274384	2.9000	S	40274253	2.7600	S	Ordinary Shares
2017-08-03		Mondrian Investment Partners Limited	738600	86980000	6.0200	L	86241400	5.9700	L	H Shares
2017-06-06		Gao Yang Investment Corporation		70528720	4.8900	L	70528720	4.8900	L	Ordinary Shares
2017-06-06	沈耀芳	Shen Yao Fang		72091720	5.0000	L	72091720	4.9900	L	Ordinary Shares
2016-11-30		Mondrian Investment Partners Limited	2183000	85812000	5.9700	L	87995000	6.1200	L	H-share
2016-08-16		Mondrian Investment Partners Limited	1387000	70496000	4.9100	L	71883000	5.0100	L	H-share
2016-01-25		Carlyle Asia Partners IV, L.P.		207181818	14.5400	L	207181818	14.5200	L	Ordinary
2016-01-25	大冢控股有限公司	Otsuka Holdings Co., Ltd.	86000000	468994120	32.8800	L	382994120	26.8500	L	Ordinary Shares
2016-01-25		Otsuka Medical Devices Co., Ltd.	86000000	468994120	32.8800	L	382994120	26.8500	L	Ordinary Shares
2016-01-25		CAP IV General Partner, L.P.		207181818	14.5400	L	207181818	14.5200	L	Ordinary
2016-01-25		CAP IV General Partner, L.P.	42140000				42140000	2.9500	S	Ordinary
2016-01-25		CAP IV L.L.C.		207181818	14.5400	L	207181818	14.5200	L	Ordinary
2016-01-25		CAP IV L.L.C.	42140000				42140000	2.9500	S	Ordinary
2016-01-25		Carlyle Asia Partners IV, L.P.	42140000				42140000	2.9500	S	Ordinary
2016-01-25		Erudite Holdings Limited		207181818	14.5400	L	207181818	14.5200	L	Ordinary
2016-01-25		Erudite Holdings Limited	42140000				42140000	2.9500	S	Ordinary
2016-01-06		GIC (Ventures) Pte. Ltd.	9662337	113669590	7.9700	L	123331927	8.6500	L	Ordinary Shares
2016-01-06		GIC Special Investments Pte. Ltd.	9662337	113669590	7.9700	L	123331927	8.6500	L	Ordinary
2016-01-06		Owap Investment Pte Ltd.	9662337	113669590	7.9700	L	123331927	8.6500	L	Ordinary Shares
2015-12-16		Otsuka Medical Devices Co., Ltd.	86000000	468994120	32.9100	L	468994120	32.9100	L	Ordinary Shares
2015-12-16	大冢控股有限公司	Otsuka Holdings Co., Ltd.	86000000	468994120	32.9100	L	468994120	32.9100	L	Ordinary Shares
2015-12-16		CAP IV General Partner, L.P.	207181818	0	0.0000	L	207181818	14.5400	L	Ordinary
2015-12-16		CAP IV L.L.C.	207181818	0	0.0000	L	207181818	14.5400	L	Ordinary
2015-12-16		Erudite Holdings Limited	207181818	0	0.0000	L	207181818	14.5400	L	Ordinary
2015-12-16		Carlyle Asia Partners IV, L.P.	207181818	0	0.0000	L	207181818	14.5400	L	Ordinary
2014-09-03	上海张江（集团）有限公司	Shanghai Zhangjiang（Group）Co.,Ltd.	64000000	285748050	20.0900	L	221748050	15.5900	L	普通股
2014-07-17		Owap Investment Pte Ltd.		113669590	8.0000	L	113669590	8.0000	L	Ordinary
2014-07-17		GIC (Ventures) Pte. Ltd.		113669590	8.0000	L	113669590	8.0000	L	Ordinary
2014-07-17		GIC Special Investments Pte. Ltd.		113669590	8.0000	L	113669590	8.0000	L	Ordinary
2014-04-27		GIC (Ventures) Pte. Ltd.	113669590	0	0.0000	L	113669590	8.0400	L	Ordinary
2014-04-27	新加坡政府投资公司	GIC Private Limited	113669590	9687000	0.6900	L	123356590	8.7200	L	Ordinary
2014-04-27		GIC Special Investments Pte. Ltd.	113669590	0	0.0000	L	113669590	8.0400	L	Ordinary
2014-04-27		Owap Investment Pte Ltd.	113669590	0	0.0000	L	113669590	8.0400	L	Ordinary
2013-07-17	尽善尽美科学基金会有限公司	Maxwell Maxcare Science Foundation Limited		217110000	15.4200	L	217110000	15.4200	L	Ordinary Shares
2013-06-28		We'Tron Capital Limited		217110000	15.4100	L	217110000	15.4100	L	Ordinary
2012-09-07	尽善尽美科学基金会有限公司	Maxwell Maxcare Science Foundation Limited	217110000	0	0.0000	L	217110000	15.2600	L	Ordinary Shares
2011-12-05		Otsuka Medical Devices Co., Ltd.		468994120	32.9700	L	468994120	33.0200	L	Ordinary Shares
2011-12-05	大冢控股有限公司	Otsuka Holdings Co., Ltd.		468994120	32.9700	L	468994120	33.0200	L	Ordinary Shares
2011-06-21		Otsuka Medical Devices Co., Ltd.	468994120	0	0.0000	L	468994120	32.5100	L	Ordinary Shares
2011-06-21	大冢制药有限公司	Otsuka Pharmaceutical Co., Ltd.	468994120	468994120	32.5100	L	0	0.0000	L	Ordinary Shares
2011-06-21	大冢控股有限公司	Otsuka Holdings Co., Ltd.	468994120	468994120	32.8800	L	468994120	32.8800	L	Ordinary Shares
2011-02-02		Gao Yang Investment Corporation	22483720	52750000	3.6600	L	75233720	5.2200	L	普通股
2011-02-02	沈耀芳	Shen Yao Fang	22483720	52750000	3.6600	L	75233720	5.2200	L	普通股
2010-09-29	大冢控股有限公司	Otsuka Holdings Co., Ltd.		468994120	33.4000	L	468994120	32.5200	L	Ordinary Shares
2010-09-29	大冢制药有限公司	Otsuka Pharmaceutical Co., Ltd.		468994120	33.4000	L	468994120	32.5200	L	Ordinary Shares
2010-09-29		Shanghai We’Tron Capital Corp.	37911000	217110000	15.0600	L	217110000	15.0600	L	Ordinary Shares
2010-09-29		Shanghai We’Tron Capital Corp.		217110000	15.4600	L	217110000	15.0600	L	Ordinary Shares
2010-09-29	上海张江（集团）有限公司	Shanghai Zhangjiang（Group）Co.,Ltd.		285748050	20.3500	L	285748050	19.8200	L	Ordinary Shares
2010-09-29	上海张江健康产品控股有限公司	Shanghai Zhangjiang Health Solution Holdings Limited		215883620	15.3800	L	215883620	14.9700	L	Ordinary Shares
2010-09-29	上海张江浩成创业投资有限公司	Shanghai Zhangjiang Haocheng Venture Capital Co., Ltd		285748050	20.3500	L	285748050	19.8200	L	Ordinary Shares
2010-09-29	上海张江科技投资（香港）有限公司	Shanghai Zhangjiang Science and Technology Investment (Hong Kong) Company Limited		285748050	20.3500	L	285748050	19.8200	L	Ordinary Shares
2010-09-29	上海张江高科技园区开发股份有限公司	Shanghai Zhangjiang Hi-Tech Park Development Co.,Ltd.		285748050	20.3500	L	285748050	19.8200	L	Ordinary Shares
2010-09-29	上海张江	Shanghai ZJ Hi-Tech Investment Corporation		285748050	20.3500	L	285748050	19.8200	L	Ordinary Shares
2010-09-29	上海张江科技创业投资有限公司	Shanghai Zhangjiang Science and Technology Investment Co.		285748050	24.8200	L	285748050	20.3500	L	Ordinary Shares
2010-09-29	中国微创投资管理有限公司	We’Tron Capital China Limited		217110000	15.4600	L	217110000	15.0600	L	Ordinary Shares
2010-09-29	中国微创投资管理有限公司	We’Tron Capital China Limited	37911000	217110000	15.0600	L	217110000	15.0600	L	Ordinary Shares
2010-09-29		Shanghai ZJ Holdings Limited		285748050	20.3500	L	285748050	19.8200	L	Ordinary Shares
2010-09-24		Credit Suisse Group AG		0	0.0000	P	0	0.0000	P	Ordinary Shares
2010-09-24		Credit Suisse Group AG		0	0.0000	S	37911000	2.7000	S	Ordinary Shares
2010-09-24		Credit Suisse Group AG	75822000	0	0.0000	L	75822000	5.4000	L	Ordinary Shares
2010-09-24		Credit Suisse AG		0	0.0000	P	0	0.0000	P	Ordinary Shares
2010-09-24		Credit Suisse AG		0	0.0000	S	37911000	2.7000	S	Ordinary Shares
2010-09-24		Credit Suisse AG	75822000	0	0.0000	L	75822000	5.4000	L	Ordinary Shares
2010-09-24	瑞士信贷（香港）有限公司	Credit Suisse (Hong Kong) Limited		0	0.0000	P	0	0.0000	P	Ordinary Shares
2010-09-24	瑞士信贷（香港）有限公司	Credit Suisse (Hong Kong) Limited		0	0.0000	S	37911000	2.7000	S	Ordinary Shares
2010-09-24	瑞士信贷（香港）有限公司	Credit Suisse (Hong Kong) Limited	75822000	0	0.0000	L	75822000	5.4000	L	Ordinary Shares
2010-09-24		Credit Suisse Group AG	37911000	75822000	5.4000	L	37911000	2.7000	L	Ordinary Shares
2010-09-24		Credit Suisse Group AG		37911000	2.7000	S	37911000	2.7000	S	Ordinary Shares
2010-09-24	大冢控股有限公司	Otsuka Holdings Co., Ltd.		468994120	40.7300	L	468994120	33.4000	L	Ordinary Shares
2010-09-24	大冢制药有限公司	Otsuka Pharmaceutical Co., Ltd.		468994120	40.7300	L	468994120	33.4000	L	Ordinary Shares
2010-09-24		Shanghai We’Tron Capital Corp.		217110000	18.8600	L	217110000	15.4600	L	Ordinary Shares
2010-09-24		Shanghai We’Tron Capital Corp.	37911000	217110000	15.4600	L	217110000	15.4600	L	Ordinary Shares
2010-09-24	上海张江（集团）有限公司	Shanghai Zhangjiang（Group）Co.,Ltd.		285748050	24.8200	L	285748050	20.3500	L	Ordinary Shares
2010-09-24	上海张江浩成创业投资有限公司	Shanghai Zhangjiang Haocheng Venture Capital Co., Ltd		285748050	24.8200	L	285748050	20.3500	L	Ordinary Shares
2010-09-24	上海张江健康产品控股有限公司	Shanghai Zhangjiang Health Solution Holdings Limited		215883620	18.7500	L	215883620	15.3800	L	Ordinary Shares
2010-09-24	上海张江高科技园区开发股份有限公司	Shanghai Zhangjiang Hi-Tech Park Development Co.,Ltd.		285748050	24.8200	L	285748050	20.3500	L	Ordinary Shares
2010-09-24	上海张江科技投资（香港）有限公司	Shanghai Zhangjiang Science and Technology Investment (Hong Kong) Company Limited		285748050	24.8200	L	285748050	20.3500	L	Ordinary Shares
2010-09-24	上海张江科技创业投资有限公司	Shanghai Zhangjiang Science and Technology Investment Co.		285748050	24.8200	L	285748050	20.3500	L	Ordinary Shares
2010-09-24		Shanghai ZJ Holdings Limited		285748050	24.8200	L	285748050	20.3500	L	Ordinary Shares
2010-09-24	中国微创投资管理有限公司	We’Tron Capital China Limited		217110000	18.8600	L	217110000	15.4600	L	Ordinary Shares
2010-09-24	中国微创投资管理有限公司	We’Tron Capital China Limited	37911000	217110000	15.4600	L	217110000	15.4600	L	Ordinary Shares
2010-09-24	上海张江	Shanghai ZJ Hi-Tech Investment Corporation		285748050	24.8200	L	285748050	20.3500	L	Ordinary Shares

回购日期	回购数量(股)	最高回购价(港元)	最低回购价(港元)	回购总价(港元)	平均回购价(港元)
2013-07-10	160000	6.1400	5.9300	960768.0000	6.005
2013-07-09	160000	6.1900	6.0100	977280.0000	6.108
2013-07-08	149000	6.2400	5.9700	905860.4000	6.080
2013-07-05	147000	6.3000	5.9500	890085.0000	6.055
2013-07-04	148000	6.4700	6.2100	931304.8000	6.293
2013-07-03	149000	6.5700	6.3000	948906.5000	6.369
2013-07-02	23000	6.4900	6.4900	149270.0000	6.490
2013-06-27	7000	6.3100	6.3100	44170.0000	6.310
2013-06-26	94000	6.1500	6.1000	577470.2000	6.143
2013-01-22	298000	4.7100	4.5700	1380604.2000	4.633
2013-01-21	620000	4.6800	4.6500	2896702.0000	4.672
2013-01-17	420000	4.4900	4.3800	1852620.0000	4.411
2013-01-16	420000	4.5100	4.4100	1876476.0000	4.468
2013-01-15	420000	4.4500	4.3600	1851570.0000	4.409
2012-12-10	145000	4.6100	4.5800	666057.5000	4.594
2012-12-07	160000	4.6100	4.5500	735056.0000	4.594
2012-12-06	155000	4.6500	4.6000	715960.5000	4.619
2012-12-05	150000	4.6200	4.5800	689820.0000	4.599
2012-12-04	650000	4.6100	4.5700	2982850.0000	4.589
2012-12-03	650000	4.6600	4.6200	3019185.0000	4.645
2012-11-30	650000	4.6300	4.5400	2974855.0000	4.577
2012-11-29	650000	4.6200	4.4700	2960880.0000	4.555
2012-11-28	376000	4.6100	4.5000	1711138.4000	4.551
2012-11-27	450000	4.6000	4.5600	2067840.0000	4.595
2012-11-26	450000	4.5700	4.5300	2049345.0000	4.554
2012-11-23	149000	4.4000	4.3000	650057.2000	4.363
2012-11-22	450000	4.3100	4.2700	1932840.0000	4.295
2012-11-21	450000	4.3000	4.2600	1929960.0000	4.289
2012-11-20	450000	4.3000	4.2400	1928205.0000	4.285
2012-11-19	535000	4.3200	4.1900	2260696.0000	4.226
2012-11-16	374000	4.3000	4.1800	1593165.2000	4.260
2012-11-15	317000	4.2000	4.1500	1328547.0000	4.191
2012-11-14	259000	4.2000	4.1300	1079278.9000	4.167
2012-11-13	444000	4.2400	4.0900	1852057.2000	4.171
2012-11-12	368000	4.2000	4.1500	1542692.8000	4.192
2012-11-09	450000	4.2200	4.0900	1877130.0000	4.171
2012-11-08	450000	4.2600	4.1100	1888785.0000	4.197
2012-11-07	900000	4.1500	4.0400	3685770.0000	4.095
2012-11-06	447000	4.1800	4.0900	1859698.8000	4.160
2012-11-05	438000	4.2100	4.0900	1818094.2000	4.151
2012-11-02	332000	4.1800	4.1000	1384639.2000	4.171
2012-11-01	154000	4.1000	4.0100	625255.4000	4.060
2012-10-24	200000	4.2000	4.0500	824900.0000	4.125
2012-10-22	1396000	4.2000	4.0500	5827462.4000	4.174
2012-10-19	250000	4.1700	4.0900	1030850.0000	4.123
2012-10-18	350000	4.3200	4.1500	1471785.0000	4.205
2012-10-17	83000	4.2700	4.2600	354376.8000	4.270
2012-10-16	178000	4.1500	4.1000	738557.6000	4.149
2012-10-15	250000	4.1400	4.0800	1030300.0000	4.121
2012-10-12	250000	4.1300	3.9500	1007500.0000	4.030
2012-10-11	250000	3.9400	3.9100	980575.0000	3.922
2012-10-10	350000	3.9800	3.8800	1371335.0000	3.918
2012-10-09	167000	4.0500	4.0100	672926.5000	4.030
2012-10-08	263000	4.0400	3.9900	1053656.9000	4.006
2012-10-05	250000	4.0500	3.9200	996525.0000	3.986
2012-10-04	250000	4.0100	3.9500	997500.0000	3.990
2012-10-03	15000	3.9000	3.8600	58150.5000	3.877
2012-09-28	200000	3.8800	3.8100	770140.0000	3.851
2012-09-27	200000	3.8000	3.7200	753160.0000	3.766
2012-09-26	101000	3.7500	3.7400	378739.9000	3.750
2012-09-24	200000	3.6500	3.5900	722700.0000	3.614
2012-09-21	200000	3.7000	3.6800	738180.0000	3.691
2012-09-20	200000	3.7000	3.6200	734300.0000	3.672
2012-09-19	200000	3.7500	3.7300	749320.0000	3.747
2012-09-18	17000	3.6000	3.5800	61060.6000	3.592
2012-09-17	200000	3.5900	3.4900	713660.0000	3.568
2012-09-14	200000	3.5800	3.5000	712900.0000	3.565
2012-09-12	37000	3.3500	3.3200	123831.6000	3.347
2012-09-11	37000	3.3500	3.3200	123831.6000	3.347
2011-11-28	300000	4.1100	3.9900	1218900.0000	4.063
2011-11-25	929000	4.2000	3.8700	3707081.6000	3.990
2011-11-24	1000000	4.3100	4.0500	4231900.0000	4.232
2011-11-15	750000	4.8000	4.7800	3598425.0000	4.798
2011-11-14	71000	4.7400	4.7000	336461.9000	4.739
2011-11-11	1950000	4.6100	4.4200	8811465.0000	4.519
2011-11-10	1500000	4.5000	4.2750	6701250.0000	4.468
2011-10-18	333000	4.7900	4.6600	1571560.2000	4.719
2011-10-17	1565000	4.7900	4.6400	7368802.5000	4.709
2011-10-14	808000	4.7000	4.6000	3770208.8000	4.666
2011-10-13	1507000	4.6600	4.4700	6934611.2000	4.602
2011-10-12	1063000	4.5700	4.5200	4854083.2000	4.566
2011-10-11	975000	4.4600	4.4000	4331340.0000	4.442
2011-10-10	633000	4.3400	4.3200	2746840.2000	4.339
2011-10-07	633000	4.3400	4.3200	2746840.2000	4.339
2011-10-06	120000	4.2900	4.2300	513612.0000	4.280
2011-10-04	2000000	4.2200	4.0200	8367000.0000	4.184
2011-10-03	858000	4.0800	3.8200	3399138.6000	3.962
2011-09-30	1305000	4.1100	3.9700	5324139.0000	4.080
2011-09-28	293000	4.0600	4.0600	1189580.0000	4.060
2011-09-27	1297000	3.9500	3.8100	5022113.7000	3.872
2011-09-26	1830000	3.9500	3.7300	7066545.0000	3.862
2011-09-23	2033000	3.8300	3.6200	7633101.8000	3.755
2011-09-22	910000	3.8000	3.6700	3402308.0000	3.739
2011-09-21	121000	3.8600	3.7900	463369.5000	3.830
2011-09-20	646000	3.8700	3.7800	2483349.9700	3.844