VOLUNTARY ANNOUNCEMENT - UPDATES ON THE CLINICAL TRIAL OF IMC-002

Hong Kong Exchanges and Clearing Limited and The Stock Exchange of Hong Kong Limited take no responsibility for the contents of this announcement make no representation as to its accuracy or completeness and expressly disclaim any liability whatsoever for any loss howsoever arising from or in reliance upon the whole or any part of the contents of this announcement.ImmuneOnco Biopharmaceuticals (Shanghai) Inc.宜明昂科生物医药技术（上海）股份有限公司 (A joint stock company incorporated in the People’s Republic of China with limited liability) (Stock Code: 1541) VOLUNTARY ANNOUNCEMENT UPDATES ON THE CLINICAL TRIAL OF IMC-002 This announcement is made by ImmuneOnco Biopharmaceuticals (Shanghai) Inc. (the “Company” together with its subsidiaries the “Group”) on a voluntary basis to inform shareholders and potential investors of the Company about the latest business development of the Group.The board (the “Board”) of directors (“Directors” and each a “Director”) of the Company is pleased to announce that the Group has obtained an investigational new drug (IND) approval for the Phase Ib/III clinical trial of IMC-002 for the treatment of neuromyelitis optica spectrum disorders (NMOSDs) from the National Medical Products Administration of the People’s Republic of China (the “NMPA”).ABOUT IMC-002 IMC-002 independently developed by the Group is a bispecific molecule targeting both cluster of differentiation 47 (CD47) and cluster of differentiation 20 (CD20). With enhanced antibody-dependent cellular phagocytosis (ADCP) activity and antibody-dependent cellular cytotoxicity (ADCC) activity IMC-002 can simultaneously bind to CD47 and CD20 expressed on malignant B cells with a higher affinity for CD20 than CD47 leading to improved therapeutic outcomes.– 1 –The Group owns the global intellectual property rights and commercial rights of IMC-002.Furthermore the Group has received an IND approval from the NMPA for the clinical trial of IMC-002 against systemic lupus erythematosus (SLE).Cautionary Statement required by Rule 18A.05 of the Rules Governing the Listing of Securities on The Stock Exchange of Hong Kong Limited: The Company cannot guarantee that it will be able to develop or ultimately market IMC-002 successfully. Shareholders and potential investors of the Company are advised to exercise due care when dealing in the shares of the Company.By order of the Board ImmuneOnco Biopharmaceuticals (Shanghai) Inc.宜明昂科生物医药技术（上海）股份有限公司 Tian Wenzhi Chairman and Executive Director Hong Kong June 21 2024 As at the date of this announcement the Board of Directors comprises (i) Dr. Tian Wenzhi Mr. Li Song and Ms. Guan Mei as executive Directors; (ii) Dr. Xu Cong Mr. Yu Zhihua and Mr. Yu Xiaoyong as non-executive Directors; and (iii) Dr. Zhenping Zhu Dr. Kendall Arthur Smith and Mr. Yeung Chi Tat as independent non- executive Directors.–2–